Research fellow, regulation of aging

Job description

• Background of the recruitment and description of the project

  
  

  Rejuvenation and aging research are gaining significant attention in the fields of biotechnology and biomedical science, with increasing investment and development activity. A key focus is on understanding and reversing aging at the molecular and cellular levels, particularly through the lens of the epigenome. This includes not only objective prediction of biological aging, but also the improvement of age-related phenotypes such as cognitive decline, muscle weakness, bone density loss, and kidney dysfunction.

  
  

  Our research is particularly interested in how environmental and lifestyle factors—such as diet and daily habits—affect not just disease risk but also physical function. We aim to uncover the underlying molecular mechanisms and clarify how they influence both the "rate" and "onset" of aging.

  
  

  At our laboratory, we are currently recruiting Special Research Scientists who are motivated to contribute to aging and age-related disease research. Our studies utilize various models including ICE mice and non-model organisms such as fish and birds, and cover areas such as dementia, sarcopenia, and age-related macular degeneration.

  
  

  We welcome researchers from diverse backgrounds—from wet-lab biology to dry-lab fields such as AI and data science. Additionally, we encourage individuals who are interested in exploring aging research from outside traditional life sciences, including those aiming to translate research findings into real-world applications or entrepreneurship.

• Work content and job description

  
  

  As part of the Regulation of Ageing project, we are looking for researchers who will be responsible for the following tasks:

  
  

  * Investigating the promotion and regulation of ageing through the Epigenome, which involves examining histone and DNA modifications to establish a novel ageing model using the ICE mouse.
  
  * Exploring various perspectives on the rate and timing of ageing, including stem cells, DNA damage, epigenome, mitochondria, and lipid metabolism in ageing models. The use of AI and Deep Learning for data analysis and the establishment of in vitro ageing experimental systems and factor isolation using CRISPR Screening are also planned.
  
  * Analyzing brain neural circuits and cellular functions (including nsRNA-seq) in brain regulation from the retina via the non-visual receptor OPN5, which can be applied to conditions such as depression, dementia, and Parkinson''s disease.
  
  * Investigating the effects of external signals on the body and ageing regulation, which may provide valuable insight into effective ageing control methods for conditions such as sarcopenia and dementia.
  
  * Developing drugs to target factors in both ICE mice and OPN5 for effective ageing control, as well as conducting research to establish start-up companies focused on social implementation of ageing control methods.

• Assigned department

  
  

  Existing departments

  
  

  Division of Molecular Biology of Aging, The Research Institute for Science and Technology (RIST)

Job type

• Researcher/Postdoc level

Research field

• Life Science - Molecular biology

Wages

• Annual Salary : 4 million yen ~ 7 million yen

Working hours

• Working hours :09:00-18:00

  
  

  Break time :12:00-13:00

  
  

  Overtime and other explanations : Discretionary work system; flexible scheduling is available according to the research plan.

Application requirements

Qualifications

• Education and Degree Requirements

  
  

  Ph.D. / Doctor

• Description

  
  

  * Ph.D. in Biology, Biomedical Sciences, Medicine, or a related field, or equivalent research achievements.
  
  * Applicants must have obtained their Ph.D. or be expected to receive their Ph.D. before the start of the appointment.
  
  * Strong background in molecular biology and cell biology, with hands-on experience in animal experiments.
  
  * A strong interest in aging research and enthusiasm for translating research findings into drug discovery and therapeutic development.

Employment Type

• Regular employee

Contract period

• Nontenured - Non-tenure track

  
  

  1 year. Contract renewed in April of each fiscal year.

  
  

  Probationary period present

  
  

  3 months

Work location

• 278-8510 Chiba 3rd Floor, Building 10, 2641 Yamazaki, Noda-shi,

Compensation

• Various systems

  
  

  Pay increase system : available

  
  

  Transportation expenses : available

• Insurance

  
  

  Employees'' Health Insurance : available

  
  

  Employees'' Pension Insurance : available

  
  

  Worker''s accident insurance : available

  
  

  Employment insurance : available

Application Considerations

Number of hired

2 person(s)

Application period

• 2026/07/13~2026/12/31 Deadline for receipt

Application method

• Attached documents

  
  

  Application Form : Online Submission

  
  

  Achievements and Activities : Online Submission

• Return of application documents

  
  

  We will dispose of all application documents responsibly.

URL of this job posting

Selection / Notification of result

• Selection

  
  

  Please send a CV and a cover letter to the below with your interests in aging research in our lab. After screening of your application, we would have an job interview.

  
  

  The blows are essential in your application.
  
  *what is your motivation to conduct researches.
  
  *what is your interest in aging field

• Notification of result

  
  

  Interview invitations and scheduling details will be sent to selected candidates within one week after the application review.

Contact details

Tokyo University of Science

Division of Molecular Biology of Aging, The Research Institute for Science and Technology (RIST)

Motoshi Hayano

0471241501

mhayano(at)rs.tus.ac.jp

* Please change (at) to @ and send it.

Notes