We are looking for Senior Research Fellows, Research Fellows and Research Assistants to join as Molecular biologists interested in RNA metabolism and transcriptional dynamics in the Patani lab at NUS. The Patani lab has played a pioneering role in neurodegenerative disease modelling focused on RNA metabolism and cellular autonomy using human patient derived iPSCs neuronal cultures. The lab is looking for creative and driven cellular and molecular biologists with experience in iPSC biology and/or RNA biochemistry to join the group. The candidate will report directly to Prof. Patani.
Beyond the wet lab personnel, the lab currently comprises dry lab scientists with whom the candidate is expected to collaborate closely. This means that the candidate has the opportunity to be involved in projects starting from experimental design through to target prioritisation, validation and mechanistic deconvolution.
The candidate will have the opportunity to develop key projects focused on the role of deregulated RNA metabolism across different neurodegenerative disorders, where the lab has published some key papers (for example: Luisier et al Nature Communications 2018; Tyzack et al Brain 2021; Ziff et al Nature Communications 2023; Ziff et al Neuron 2023; Neeves et al Science Advance 2025) and reviews (for example: Petrić Howe et al Trends in Neuroscience 2023; Patani et al Nature Reviews Neurology 2023; Balendra et al Lancet Neurology 2025)
The specific details for the candidate's own projects will be developed in close discussion with Prof. Patani.
Candidate requirements:
Demonstrable experience working in a research environment conducting rigorous/thorough investigations (Required). Prior experience working with iPSCs and directed differentiation (Desired). Demonstrable prior experience in molecular biology, esp. probing RNA-protein interactions e.g. RIP, CLIP, RBPome capture methods (Desired) Prior experience investigating transcriptional, splicing and/or post-transcriptional mechanisms of disease (Desired). Some knowledge/interest in molecular biology and neuroscience (Desired).
