Research Fellow, School of Materials Science and Engineering - JOBS.ac.kr(잡스)

{"job":{"jobId":1209942,"fk_accountId":null,"fk_organizationId":507,"fk_adminAccountId":null,"title":"Research Fellow, School of Materials Science and Engineering","description":"\n\nSchool of Materials Science and Engineering  is looking for a candidate to join them as a Research Fellow.\n\n\nThe overarching objective of this project is to develop an in depth understanding of the enzymatic activity of proteases reconstituted in the membrane of lipids and biomimetic polymer capsules and to use such constructs to identify potential peptide hits for future diagnostic applications. In the area of diagnostics, we foresee applications for remote detection of pathogens in water and food.\n\n\nThe work to be undertaken focuses on a class of membrane bound proteases belonging to the Omptin family. In particular proteases like OmpT and PtgE present in the outer membrane of E.Coli and Salmonella. The work will be undertaken in close collaboration with scientists from UC Davis and Northwestern University in the US.\n\n\nThe Research Fellow should work jointly with scientists from the above universities to develop peptide libraries to probe activity of the reconstituted proteases using Self-Assembled Monolayers for matrix-assisted laser Desorption/Ionization – Mass Spectrometry (SAMDI-MS) and biophysical methodologies. The hits from these libraries and proteomics screening approaches will be used develop assays and novel sensor concepts for detection of bacteria.\n\n\nKey Responsibilities: \n\n\n<ul>\n<li>Design and carry out high quality scientific experiments required to achieve project goals. This will include:\n\t<ul>\n<li>Production, purification, and characterization of relevant omptin proteases in various membrane environments (detergents, lipids, and polymer capsules)</li>\n<li>Advanced analysis of substrate preferences and enzymatic activities of the proteases and their degradation products, primarily using optical spectroscopy and advanced biophysical techniques</li>\n<li>Design and optimise short peptide libraries to identify top peptide hits for target omptin protease</li>\n<li>Advanced analysis and characterization of reporter polymer/oligomers for optical detection of protease activity primarily using optical spectroscopy (UV-Vis, fluorescence, Circular Dichroism, etc), and DLS</li>\n</ul>\n</li>\n<li>Keep records of work, analyze data, and assist in the preparation of manuscripts for publications</li>\n<li>Present scientific data at scientific conferences, at lab/group meetings, and to collaborators</li>\n<li>Interact efficiently with project members and other team members working on similar topics</li>\n<li>Assist in training students and other part-time hourly personnel in experimental techniques and the proper use of equipment in the laboratory through various laboratory related activities</li>\n<li>Keep the workplace and laboratory organized in a clean and safe manner in accordance with established procedures and university policies</li>\n<li>Maintain lab instruments in operational condition and adhere to proper procedures for the management and disposal of hazardous waste. Expected outcome is a proper adherance to all health and safety inspection protocols and regulations</li>\n</ul>\n\n\nRequirements: \n\n\n<ul>\n<li>PhD in protein/enzyme engineering, materials science, bioanalytics or chemistry</li>\n<li>Preferably have a solid background in bioanalytics, protein engineering, enzymology, and/or peptide library design</li>\n<li>Take part in the development of reporter polymers/oligomers for optical detection of protease activity</li>\n<li>Ability to work independently in a multidisciplinary environment involving physicists, chemists, biologists, engineers and materials scientists</li>\n</ul>\n\n\nWe regret that only shortlisted candidates will be notified.\n\n\n","pdfUrl1":null,"location":"Singapore","location1":"아시아","location2":null,"location3":null,"type":"2","applyUrl":"https://ntu.wd3.myworkdayjobs.com/en-US/Careers/job/NTU-Main-Campus-Singapore/Research-Fellow_R00001088-1","fileUrl1":null,"fileUrl2":null,"fileUrl3":null,"fileUrl4":null,"fileUrl5":null,"fileUrl6":null,"fileUrl7":null,"workingHour":"Full Time","contractType":"Permanent","salary":null,"original_id":"UNI|224588","original_domain":"https://www.timeshighereducation.com/unijobs","original_url":"https://www.timeshighereducation.com/unijobs/listing/224588/research-fellow-school-of-materials-science-and-engineering/?LinkSource=PremiumListing","original_isPremium":"true","closeType":2,"closedAt":null,"requireEducation":0,"managerTel":null,"managerFax":null,"managerEmail":null,"managerName":"NANYANG TECHNOLOGICAL UNIVERSITY","managerPhone":null,"managerAddress":null,"log_hit":1,"log_like":0,"publishState":1,"organizationName":null,"organizationName_en":null,"organizationName_alt":null,"createdAt":"2020-09-08T00:00:00.000Z","updatedAt":"2020-09-18T11:12:16.000Z"},"organization":{"organizationId":507,"lv1Id":null,"lv2Id":null,"name":"Nanyang Technological University, Singapore","name_en":"Technological University","name_alt":",Nanyang Technological University,NANYANG TECHNOLOGICAL UNIVERSITY,","introduction":"A research-intensive public university, NTU Singapore has 33,000 undergraduate and postgraduate students in the colleges of Engineering, Business, Science, and Humanities, Arts and Social Sciences, and at its Lee Kong Chian School of Medicine which was established jointly with Imperial College London.&nbsp;Named the world’s fastest-rising young university by Times Higher Education, Nanyang Technological University (NTU Singapore) is also one of the youngest in the global league of universities.&nbsp;Its 200-hectare (500 acres) garden campus has frequently been named among the Top 15 most beautiful in the world. An environmentally sustainable campus, 95 per cent of its buildings are Green Mark Platinum-certified (equivalent to LEED-Platinum certification in the USA).Beyond its picturesque buildings and lush greenery, NTU has a vision to transform its vast grounds into a Smart Campus that embraces digital technology to support learning and discovery, and improve the sustainability of resources.&nbsp;The NTU Smart Campus is already a living testbed for various sustainable and energy-efficient technologies. NTU strives to serve as a model for other communities in Singapore and around the globe by demonstrating how advanced tech-enabled solutions can help improve everyday life in a sustainable manner.&nbsp;For example, on the NTU Smart Campus, it already has a number of partnerships with leading players such as BMW, Volvo Bus, Blue Solutions and SMRT to drive the future of smart transportation, developing solutions for both electric and autonomous vehicles.&nbsp;Interdisciplinary in focus, NTU’s high-impact research includes areas of global concern, such as artificial intelligence, robotics, sustainability, healthcare, new media and future learning. It hosts two national research centres of excellence, the Singapore Centre on Environmental Life Sciences Engineering (SCELSE) and Earth Observatory of Singapore (EOS), tackling important questions in environment and medicine.&nbsp;NTU is also home to world-class institutes. The National Institute of Education trains all teachers in Singapore, which is known for having one of the most successful education systems in the world. Other key institutes are the Nanyang Environment &amp; Water Research Institute, and the Energy Research Institute @ NTU.","logoImg":"","logoImgSquare":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/sdujfsjlkrfs_1035409752294.png","homepageUrl":"https://www.ntu.edu.sg","infoUrl":"https://www.timeshighereducation.com/world-university-rankings/nanyang-technological-university-singapore","country":"SG","state":"Singapore","location":"아시아","address":"50 Nanyang Avenue, 639798, Singapore","phoneNumber":"+65 6791 1744","faxNumber":"","type":1,"univType1":"대학","univType2":"대학교","univType3":"공립","univType4":"본교","establishedAt":"1991-01-05T00:00:00.000Z","count_majors":null,"count_students":null,"meta_competitiveness":"","publishState":1,"updatedAt":"2020-03-18T16:16:59.000Z","createdAt":"2020-03-04T20:13:07.000Z","default_1_bannerImage":null,"default_1_bannerImageMobile":null,"default_2_bannerImage":null,"default_2_bannerImageMobile":null,"default_3_bannerImage":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/NANYANGtechnology_147034590338.jpg","default_3_bannerImageMobile":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/NANYANGtechnology_142258133927.jpg"}}