{"job":{"jobId":1210837,"fk_accountId":null,"fk_organizationId":494,"fk_adminAccountId":null,"title":"Research Associate","description":"\n\n<p>The postholder will be a key researcher in an MRC-funded project to study the mechanisms of response and resistance to novel epigenetic therapies in Acute Myeloid Leukaemia (AML).  This position will be supervised by Dr Lynn Quek, based in King’s College London’s Denmark Hill Campus.</p>\n\n\n<p>AML is an aggressive bone marrow cancer which is incurable in the majority of patients. Our focus is to improve our understanding this disease with an ultimate aim to translate this knowledge to better treatments for patients.  The focus of our research is to better understand the biology of leukaemia propagating cells in patient-derived AML which are mutated in isocitrate dehydrogenase (IDH) 1 and 2 genes.  This important group of AMLs account for 20-30% of all AMLs. </p>\n\n\n<p>Inhibitors of mutant IDH enzymes such as Enasidenib have recently been developed and FDA-approved to treat IDH-mutant AML.  We have shown that Enasidenib restores blood function in AML patients by inducing differentiation of leukaemic cells previously unable to differentiate normally into mature blood cells (Amatangelo et al. Blood, 2017).  We recently described the clonal dynamics of response and resistance to Enasidenib therapy in patients and demonstrated the impact of clonal heterogeneity on the function of AML cells in vivo (Quek et al. Nature Medicine, 2018). </p>\n\n\n<p>We are looking for an ambitious research scientist who takes pride in performing scientific work to high technical standards, has excellent organisation skills, is ready to take on new challenges.  This postholder will be a key member of a team to study the metabolic and epigenetic events which underlie cell fate decisions in human patient IDH-mutant AML cells treated with IDH inhibitors.</p>\n\n\n<p>This work requires expertise in flow cytometry and cell sorting, tissue culture, gene-editing techniques, in vitro functional assays, and genomics (including DNAseq, RNAseq, MethylSeq and ATACseq). Training in more advanced techniques (e.g. flow-sorting, single cell genomics) will be offered, and the postholder will be expected to be self-driven in developing new skills.   The postholder will have the opportunity to become experts in state-of-the-art single cell multi-genomic analyses, and acquire computational skills.  We are able to offer training bioinformatics and encourage researchers to perform computational analysis of their own data. </p>\n\n\n<p>We are looking for a candidate who has excellent research skills and who is able to demonstrate self-motivation, independent critical thinking, flexibility and good teamwork. This post will be ideal for a committed scientist looking for their first or second post-doctoral position, with the opportunity to manage their own project.  They will gain most from this post by having a high level of commitment to this project and a true passion for furthering clinical scientific research. The successful candidate will also benefit from being able to work with a research assistant in this project.</p>\n\n\n<p>Dr Quek is especially interested in helping promising researchers develop their career.  This project will provide excellent scientific and technical training, working in an area that has direct relevance to patient care. </p>\n\n\n<p>Full-time: 35 hours per week\nContract: Fixed-term for 17 months</p>\n\n\n","pdfUrl1":null,"location":"London (Central), London (Greater) (GB)","location1":"유럽","location2":null,"location3":null,"type":"2","applyUrl":"https://jobs.kcl.ac.uk/gb/en/job/003904/Research-Associate","fileUrl1":null,"fileUrl2":null,"fileUrl3":null,"fileUrl4":null,"fileUrl5":null,"fileUrl6":null,"fileUrl7":null,"workingHour":"Full Time","contractType":"Fixed Term","salary":"£38,304 - £41,517 Per Annum, Including London","original_id":"UNI|222776","original_domain":"https://www.timeshighereducation.com/unijobs","original_url":"https://www.timeshighereducation.com/unijobs/listing/222776/research-associate/?LinkSource=PremiumListing","original_isPremium":"true","closeType":2,"closedAt":null,"requireEducation":0,"managerTel":null,"managerFax":null,"managerEmail":null,"managerName":"KINGS COLLEGE LONDON","managerPhone":null,"managerAddress":null,"log_hit":1,"log_like":0,"publishState":1,"organizationName":null,"organizationName_en":null,"organizationName_alt":null,"createdAt":"2020-08-25T00:00:00.000Z","updatedAt":"2020-09-18T12:00:37.000Z"},"organization":{"organizationId":494,"lv1Id":null,"lv2Id":null,"name":"King’s College London","name_en":"King's College London","name_alt":",King’s College London,KINGS COLLEGE LONDON,","introduction":"<p>King’s is a leading university providing world-class teaching and cutting-edge research. We are ranked sixth in the UK for the quality and quantity of research activity (Research Excellence Framework 2014). King’s has played a major role in many of the advances that shape modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar. King’s continues to lead the way on research and pioneers new ideas to make the world a better place.</p><p>&nbsp;</p><p>King’s is London’s most central university, with five campuses linked through the heart of the capital, enabling us to build partnerships with key London institutions and form international conversations. We collaborate on research projects, share teaching resources and create internship opportunities to enhance our students’ experience. Current partners include the British Library, British Museum, National Gallery, Shakespeare’s Globe, Southbank Centre, Tate Modern, and more. Our central location and varied partnerships allow students to get connected in one of the world’s most dynamic cities.</p><p>King’s is not only an enriching experience from an academic perspective – we have a diverse and active student community, with almost 30,000 students from some 150 countries worldwide.</p>","logoImg":"","logoImgSquare":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/fdoip_897356079989.png","homepageUrl":"https://www.kcl.ac.uk/study","infoUrl":"https://www.timeshighereducation.com/world-university-rankings/kings-college-london","country":"GB","state":"London","location":"유럽","address":"Strand, London, WC2R 2LS, United Kingdom","phoneNumber":"+44 20 7836 5454","faxNumber":"","type":1,"univType1":"대학","univType2":"대학교","univType3":"","univType4":"본교","establishedAt":"1829-01-05T00:00:00.000Z","count_majors":null,"count_students":null,"meta_competitiveness":"","publishState":1,"updatedAt":"2020-04-01T17:59:11.000Z","createdAt":"2020-03-04T20:13:07.000Z","default_1_bannerImage":null,"default_1_bannerImageMobile":null,"default_2_bannerImage":null,"default_2_bannerImageMobile":null,"default_3_bannerImage":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/KINGSCOLLEGELONDON_1254411307436.jpg","default_3_bannerImageMobile":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/KINGSCOLLEGELONDON_1398722695382.jpg"}}