Research Associate - JOBS.ac.kr(잡스) - 대한민국 최대 석박사 채용정보, 잡스!

{"job":{"jobId":1449174,"fk_accountId":null,"fk_organizationId":494,"fk_adminAccountId":null,"title":"Research Associate","description":"\n\nJob description\n\n\nThe antibody discovery group wishes to appoint a Postdoctoral Research Associate with experience in flow cytometry, in vivo cancer models and cell-based cancer cell/immune/antibody functional assays, to join its established Cancer Antibody Discovery &amp; Immunotherapy Group research programme. This post will focus on developing novel IgE-based cancer therapeutics and evaluating candidates for translation and commercialization. The post will be integrated into the academic team’s translational research activities, led by Prof. Sophia Karagiannis.    \n\n\nThe postholder will conduct flow cytometric in vitro/ex vivo antibody functional studies, develop and interrogate in vivo rodent models of cancer, working closely with two appointed researchers, liaising with academic researchers and commercial, clinical and academic collaborators. The programme is conducted to specific deliverables and strict deadlines. Therefore, the position will suit a highly-motivated and focused team player, with strong communication and collaborative skills.   \n\n\nThis post is not CoS compliant. \n\n\nThis post will be offered on an a fixed-term contract until 31st December 2021.\n\n\nThis is a full-time post.\n\nKey responsibilities\n\nExamine the efficacy, safety and mechanisms of action of a tumour antigen-specific IgE antibody by multicolour flow cytometry, flow cytometric sorting, cell-based and ELISA methodologies, to include tumour cell cytotoxicity and phagocytosis functional assays   \n\n\nConduct efficacy, safety and mechanisms of action studies of tumour antigen-specific IgE antibodies using patient and healthy volunteer immune cells, whole blood and sera  \n\n\nDesign and implement in vivo mouse model systems of cancer featuring human immune cell engraftment for cancer immunotherapy with antibodies   \n\n\nDesign and implement immunocompetent in vivo rat model systems of cancer to examine IgE immunotherapy  \n\n\nImmunomonitoring of blood and tumour lesions through novel medium-throughput screening, characterisation and evaluation studies using a range of cell-based functional assays and flow cytometric/flow sorting methodologies   \n\n\nAssist in project management.  \n\n\nHelp with supervision of PhD students and junior staff.   \n\n\nContributions to writing of reports, grant applications, new patent applications and publications for appropriate scientific journals and present research findings at scientific meetings.   \n\n\nDesign and implement antibody engineering and efficacy testing   \n\n\nDesign and production of tumour cell lines transfected with tumour antigens to be used for antibody immunotherapy evaluations in vitro and in vivo   \n\n\nCloning and expression of antibodies of different specificities and species using molecular biology approaches  \n\n\nPrimer design, sequencing of heavy and light chain of novel fully human antibodies against cancer antigens   \n\n\nConduct immunohistochemical evaluations to examine expression of tumour antigen target, Fc receptors and immune cell infiltration in patient tumour lesions, tissue microarrays, and animal tumours and other tissues  \n\n\nCommunication &amp; networking   \n\n\nFacilitate and maintain effective communication within immediate research group and with clinical and academic groups within the Unit/Department/Division   \n\n\nWork closely with our academic and clinical collaborators in Dermatology/Genetics, Cancer Studies, Allergy and Early Phase Trial Unit for the collation and analyses of data generated from research and clinical studies   \n\n\nWork in collaboration with the Research Associate and Research Fellow (Grade 7) appointed in the programme. • Interact effectively with external commercial and academic partners to present data when required.  \n\n\nDecision making, planning &amp; problem solving  \n\n\nWork effectively to specific deliverables and to strict deadlines   \n\n\nTrouble-shooting antibody screening, and antibody/protein functional and cloning technologies in the laboratory   \n\n\nCompliance with the Ethical regulations imposed by King’s College London, Guy’s and St Thomas’ NHS Trust and the Human Tissue Act.   \n\n\nCompliance with intellectual property rights, and the Data Protection Act 1998.  \n\n\nService delivery   \n\n\nDesign and implementation of multi-parameter flow cytometric and cell-based functional assays to study tumour antigen-specific IgE and IgG antibody efficacy, safety and mechanisms of action   \n\n\nDesign and implement in vitro and in vivo model systems of cancer suitable for dissecting cancer-associated inflammation, immune responses and for evaluating immunotherapy approaches including monoclonal antibodies   \n\n\nCloning and expression of different species monoclonal antibodies of the IgE and IgG class using molecular biology approaches   \n\n\nDesign and implementation of tumour cell lines transfected with tumour antigens to be used for antibody immunotherapy evaluations in vitro and in vivo   \n\n\nIsolation and purification of lymphocytes from human and animal specimens   \n\n\nPrimer design, sequencing of heavy and light chain of novel fully human antibodies against cancer antigens  \n\n\nEx vivo and ELISA assays of blood analytes.   \n\n\nMammalian cell culture, transient and stable transfection of plasmid DNA.   \n\n\nMedium-scale production of recombinant cultures   \n\n\nIsolation of RNA from mammalian cells and RT-PCR analysis.   \n\n\nExpression cloning in competent systems   \n\n\nMammalian cell harvest, measurement of antibody titres.   \n\n\nIsolation and purification of antibodies and proteins by chromatographic methods e.g. affinity chromatography, FPLC, HPLC etc.  \n\n\nAnalysis &amp; research   \n\n\nKeep up with research developments in the field of cancer immunology, immunotherapy and antibody discovery and apply knowledge to experimental interpretations   \n\n\nRecord, analyse and write up the results of experiments   \n\n\nPrepare and present findings of research activity to colleagues for review purposes   \n\n\nPresent work and other material at laboratory meetings   \n\n\nPresent work and other material at meetings with external collaborators as required   \n\n\nPresent research findings at scientific meetings as required   \n\n\nPrepare progress reports on research for external partners as required   \n\n\nPrepare progress reports on research for funding bodies as required   \n\n\nPrepare data for and contribute to writing of manuscripts and grant applications and new patent applications as require  \n\n\nTeam work, teaching &amp; learning support   \n\n\nWork closely with an interdisciplinary team of scientists in the antibody discovery programme that include two Research Associates, a Clinical Lecturer, a Clinical Fellow, a PhD student and two Research Technicians focusing on different aspects of cancer immunotherapy with antibodies   \n\n\nInteract closely and highly effectively with the Research Associate (Grade 7) appointed to this programme on a daily basis   \n\n\nWork through close interactions with colleagues in Allergy and Asthma, Cell and Molecular Biophysics, Imaging Sciences and with clinical academic colleagues in Cancer Studies   \n\n\nWork through close interactions with clinical oncology and early clinical trials unit (Prof. James Spicer) and the Breakthrough Breast Cancer Unit (Prof. Andrew Tutt) at Guy’s Hospital   \n\n\nAssist with supervision and mentorship of PhD students and junior staff  \n\n\nSensory/physical demands &amp; work environment:  \n\n\nCarry out tasks that require the learning of certain skills   \n\n\nRequired to be aware of the risks in the laboratory and clinical work environment  \n\n\nThe above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.  \n\n\nSkills, knowledge, and experience\n\n\n\nEssential criteria \n\n\n•         PhD awarded in Biological Sciences, Cancer Biology, Cancer Immunology, Molecular Biology, or equivalent of PhD in Biological Sciences, Molecular Biology, Cancer Biology, Cancer Immunology or equivalent near completion \n\n\n•         BSc in Molecular Biology, Immunology, Biophysics, Biochemistry or related subject \n\n\n•         Cell-based functional evaluations (e.g. cancer cell viability, cell signaling, antibody-dependent cellular cytotoxicity/phagocytosis) \n\n\n•         In vivo models of cancer \n\n\n•         Tumour immunology, immunomodulation and immunotherapy, including monoclonal antibody direct/effector functions \n\n\n•         Multiparameter flow cytometry \n\n\n•         Working with in vivo models of cancer (e.g. for cancer immunotherapy, such as antibody immunotherapies \n\n\n•         Isolation and purification of lymphocytes (e.g. monocytes, NK cells, basophils, B lymphocytes) and tumour cells from human and animal specimens \n\n\n•         Experience in antibody and/or protein cloning and purification techniques (e.g. affinity purification,ion exchange and reversed phase HPLC) \n\n\n•         Organised, highly motivated, focused towards high quality deliverables and able to meet strict deadlines \n\n\n•         Excellent team player able to work as part of an interdisciplinary team \n\n\n•         Ability to take initiative in problem solving and working independently \n\n\n \n\n\nDesirable criteria \n\n\n•         Experience in ELISA-style assays \n\n\n•         Immunohistochemistry \n\n\n•         Antibody and immune cell functional, potency and efficacy assays and antibody effector function evaluations (e.g. ADCC, ADCP, mast cell degranulation, basophil activation) \n\n\n•         Single cell PCR \n\n\nPlease note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6. \n\n\nThis advertisement does not meet the requirements for a Certificate of Sponsorship under Home Office regulations and therefore the university will not be able to offer sponsorship for this role.\n\n\nThis post is subject to Disclosure and Barring Service and Occupational Health clearance.\n\n\n","pdfUrl1":null,"location":"London (Greater) (GB)","location1":"유럽","location2":null,"location3":null,"type":"2","applyUrl":"https://jobs.kcl.ac.uk/gb/en/job/008406/Research-Associate","fileUrl1":null,"fileUrl2":null,"fileUrl3":null,"fileUrl4":null,"fileUrl5":null,"fileUrl6":null,"fileUrl7":null,"workingHour":"Full Time","contractType":"Fixed Term","salary":"£38,304, including London Weighting Allowance","original_id":"UNI|230067","original_domain":"https://www.timeshighereducation.com/unijobs","original_url":"https://www.timeshighereducation.com/unijobs/listing/230067/research-associate/?LinkSource=PremiumListing","original_isPremium":"true","closeType":2,"closedAt":null,"requireEducation":0,"managerTel":"","managerFax":null,"managerEmail":null,"managerName":"KINGS COLLEGE LONDON","managerPhone":null,"managerAddress":null,"log_hit":0,"log_like":0,"publishState":1,"organizationName":null,"organizationName_en":null,"organizationName_alt":null,"createdAt":"2020-10-19T00:00:00.000Z","updatedAt":"2020-10-19T20:56:53.000Z"},"organization":{"organizationId":494,"lv1Id":null,"lv2Id":null,"name":"King’s College London","name_en":"KINGS COLLEGE LONDON","name_alt":",King’s College London,KINGS COLLEGE LONDON,","introduction":"King’s is a leading university providing world-class teaching and cutting-edge research. We are ranked sixth in the UK for the quality and quantity of research activity (Research Excellence Framework 2014). King’s has played a major role in many of the advances that shape modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar. King’s continues to lead the way on research and pioneers new ideas to make the world a better place.&nbsp;King’s is London’s most central university, with five campuses linked through the heart of the capital, enabling us to build partnerships with key London institutions and form international conversations. We collaborate on research projects, share teaching resources and create internship opportunities to enhance our students’ experience. Current partners include the British Library, British Museum, National Gallery, Shakespeare’s Globe, Southbank Centre, Tate Modern, and more. Our central location and varied partnerships allow students to get connected in one of the world’s most dynamic cities.King’s is not only an enriching experience from an academic perspective – we have a diverse and active student community, with almost 30,000 students from some 150 countries worldwide.","logoImg":"","logoImgSquare":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/fdoip_897356079989.png","homepageUrl":"https://www.kcl.ac.uk/study","infoUrl":"https://www.timeshighereducation.com/world-university-rankings/kings-college-london","country":"GB","state":"London","location":"유럽","address":"Strand, London, WC2R 2LS, United Kingdom","phoneNumber":"+44 20 7836 5454","faxNumber":"","type":1,"univType1":"대학","univType2":"대학교","univType3":"","univType4":"본교","establishedAt":"1829-01-05T00:00:00.000Z","count_majors":null,"count_students":null,"meta_competitiveness":"","publishState":1,"updatedAt":"2021-03-23T10:36:30.000Z","createdAt":"2020-03-04T20:13:07.000Z","default_1_bannerImage":null,"default_1_bannerImageMobile":null,"default_2_bannerImage":null,"default_2_bannerImageMobile":null,"default_3_bannerImage":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/KINGSCOLLEGELONDON_1254411307436.jpg","default_3_bannerImageMobile":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/KINGSCOLLEGELONDON_1398722695382.jpg"}}