{"job":{"jobId":2004,"fk_accountId":null,"fk_organizationId":610,"fk_adminAccountId":null,"title":"Research Fellow, Faculty of Medicine and Health","description":"\n<p><strong>Are you an ambitious researcher looking for your next challenge? Do you have a background in Cancer Biology, Immunology or Virology? Do you want to further your career in one of the UK’s leading research-intensive Universities?</strong></p>\n<p><strong>A new paradigm in virus-mediated immunotherapy for liver cancer</strong></p>\n<p>We are seeking a research fellow to work on a new approach to liver cancer immunotherapy in the laboratory of Dr Stephen Griffin. You will use a range of molecular immunology and cell biology approaches to study therapeutic immune responses to liver cancer, driven by a new virus-based immunotherapy.</p>\n<p>Advanced liver cancer is the fastest-growing cause of cancer-related deaths worldwide and current targeted therapy extends life expectancy by only a matter of months. However, harnessing the power of our own immune systems – immunotherapy - is showing increasing promise for the treatment of otherwise incurable malignancies. Cancer-killing, or “Oncolytic” viruses are increasingly used to evoke therapeutic immune responses in cancer patients, an example of which is now commonly used to treat malignant melanoma in the skin. We have discovered that modifying a particular oncolytic virus to prevent its ability to replicate dramatically improves therapy in preclinical models of liver cancer, as well as promoting synergy with the targeted cancer drug, Sorafenib.</p>\n<p>This four-year project, funded by the Medical Research Council (MRC), seeks to both optimise and understand how the modified virus co-operates with Sorafenib to evoke immune responses against malignant hepatic cells. In particular, it will explore the immunological mechanisms that distinguish effective therapy within both primary human liver tissue and preclinical models of liver cancer. We will employ a range of techniques spanning functional immunology, molecular virology and cell biology, histochemical and immunofluorescence tissue analysis, as well as next generation transcriptomics designed to discriminate immunological phenotypes. The objective will be to achieve comprehensive understanding of the fundamental processes by which host immune responses target liver cancers, as well as providing the foundation for future clinical studies exploring this novel therapeutic approach.</p>\n<p>You will have a background in cancer/cell biology, immunology or virology, and an interest in applying that expertise to the study of tumour immunotherapy. You will join a team of researchers focussing on the mechanisms of virus-host interactions in the cancer field.</p>\n<p><strong>To explore the post further or for any queries you may have, please contact:</strong> </p>\n<p>Dr Steve Griffin, Associate Professor\nTel: (+44)113 3438637, Email: <a data-mz=\"\" href=\"mailto:s.d.c.griffin@leeds.ac.uk\" rel=\"no-follow\">s.d.c.griffin@leeds.ac.uk</a> </p>\n<p><em>The University of Leeds is committed to providing equal opportunities for all and offers a range of <u><a data-mz=\"\" href=\"http://hr.leeds.ac.uk/homepage/4/policies\" rel=\"no-follow\">family friendly policies</a></u>. The University is a charter member of Athena SWAN and holds the Bronze award. The School of Medicine holds the Gold award. We are committed to being an inclusive medical school that values all staff, and we are happy to consider job share applications and requests for flexible working arrangements from our employees.</em></p>\n<p><b>Location: </b> Leeds - St James University Hospital\n<b>Faculty/Service: </b> Faculty of Medicine & Health\n<b>School/Institute: </b> Leeds Institute of Medical Research (LIMR)\n<b>Section: </b> Haematology & Immunology\n<b>Category: </b> Research\n<b>Grade: </b> Grade 7\n<b>Salary: </b> £33,797 to £40,322 p.a.\n<b>Working Time: </b> Full time\n<b>Post Type: </b> Full Time\n<b>Contract Type: </b> Fixed Term (Available from 1 April 2020 for 4 years) \n<b>Closing Date: </b> Thursday 27 February 2020 \n<b>Downloads: </b> <a data-mz=\"\" href=\"https://jobs.leeds.ac.uk/Upload/vacancies/files/17462/Candidate%20Brief%20-%20MHLMR1006.pdf&embedded=true\" rel=\"no-follow\" target=\"_blank\">Candidate Brief</a> </p>\n","pdfUrl1":null,"location":"Leeds, United Kingdom","location1":"유럽","location2":null,"location3":null,"type":"2","applyUrl":"https://jobs.leeds.ac.uk/vacancy.aspx?ref=MHLMR1006","fileUrl1":"","fileUrl2":"","fileUrl3":"","fileUrl4":"","fileUrl5":null,"fileUrl6":null,"fileUrl7":null,"workingHour":"Full Time","contractType":"Fixed Term","salary":"£33,797 to £40,322 p.a.","original_id":"UNI|195070","original_domain":"https://www.timeshighereducation.com/unijobs","original_url":"https://www.timeshighereducation.com/unijobs/listing/195070/research-fellow-faculty-of-medicine-and-health/?LinkSource=PremiumListing","original_isPremium":"true","closeType":2,"closedAt":null,"requireEducation":10,"managerTel":"","managerFax":"","managerEmail":"s.d.c.griffin@leeds.ac.uk","managerName":"UNIVERSITY OF LEEDS","managerPhone":"","managerAddress":null,"log_hit":5,"log_like":0,"publishState":1,"organizationName":null,"organizationName_en":null,"organizationName_alt":null,"createdAt":"2020-01-29T15:00:00.000Z","updatedAt":null},"organization":{"organizationId":610,"lv1Id":null,"lv2Id":null,"name":"University of Leeds","name_en":"University of Leeds","name_alt":",","introduction":"<p>The University of Leeds is a redbrick university in the city of Leeds, West Yorkshire.</p><p>Officially founded in the early 20th century, the university’s origins can be traced back to the 19th century, when the Yorkshire College of Science was established. It was one of the first colleges in the UK for students of all faiths and backgrounds, set up to challenge the exclusivity of Oxford and Cambridge.</p><p> </p><p>Initially the college focussed purely on scientific studies before eventually introducing Classics, History and Modern Literature. This led the Yorkshire College of Science to become the Yorkshire College and in 1904, King Edward VII granted Leeds its own Charter as an independent institution.</p><p>Today, the University of Leeds is among the Russell Group of research-intensive universities. It offers over 500 undergraduate and more than 200 postgraduate-degree courses. Teaching staff have been awarded 26 National Teaching Fellowships – more than any other university in the UK.</p><p>With over 30,000 students – 5,000 of them international, from more than 100 countries – the university prides itself on being a multicultural and international institution.</p><p> </p><p>Its partnership with Southwest Jiaotong University in Chengdu, China was the first overseas school to be set up by the University of Leeds and offers students a unique UK-Chinese engineering curriculum.</p><p>The university is located on a single-site campus, just a short walk from Leeds’ vibrant city centre, with access to art galleries, museums, shopping and sports facilities, as well as green spaces.</p><p> </p><p>Leeds University Union offers over 250 clubs and societies and its students' union was the first in the UK to be awarded ‘excellent’ status by the National Union of Students (NUS) as part of its Quality Students' Unions accreditation scheme.</p><p>A recent £520m has been invested into transforming its campus, which includes state-of-the-art sport and well-being facilities, a 25m eight lane swimming pool and the largest fitness suite of any UK university</p><p>Leeds alumni include the late historian Herbert Read, the singer-songwriter Corinne Bailey Rae, and the astronaut Piers Sellers.</p>","logoImg":"","logoImgSquare":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/sajdlkda_414175179581.png","homepageUrl":"https://www.leeds.ac.uk/","infoUrl":"https://www.timeshighereducation.com/world-university-rankings/university-leeds","country":"GB","state":"West Yorkshire","location":"유럽","address":"171-173 Woodhouse Lane, Leeds, West Yorkshire, LS2 9JT, United Kingdom","phoneNumber":"+44 113 243 1751","faxNumber":"","type":1,"univType1":"대학","univType2":"대학교","univType3":"","univType4":"본교","establishedAt":"1904-01-05T00:00:00.000Z","count_majors":null,"count_students":null,"meta_competitiveness":"","publishState":1,"updatedAt":"2020-03-26T01:19:01.000Z","createdAt":"2020-03-04T11:13:07.000Z","default_1_bannerImage":null,"default_1_bannerImageMobile":null,"default_2_bannerImage":null,"default_2_bannerImageMobile":null,"default_3_bannerImage":null,"default_3_bannerImageMobile":null}}