Research Fellow, Cancer Science Institute - JOBS.ac.kr(잡스) - 대한민국 최대 석박사 채용정보, 잡스!

{"job":{"jobId":2422078,"fk_accountId":null,"fk_organizationId":483,"fk_adminAccountId":null,"title":"Research Fellow, Cancer Science Institute","description":"\n\nJob Description\n\n\nA postdoctoral position is available immediately in Prof. Yoshiaki Ito’s lab. The successful candidate will study one of the following on-going projects.\n\n\n<ol>\n<li>Characterization of two types of stem cells in stomach.\n<ul>\n<li>It is widely accepted that cancer originates from aberrant regulation of tissue stem cells. However, studies of tissue stem cells in many organs are still at early stages. There are two types of stem cells in stomach: rapidly proliferating stem cells (Isthmus stem cells) and dormant stem cells, a subpopulation of terminally differentiated chief cells at the gland base.  Isthmus stem cells are responsible for generating all cell types in the stomach under the homeostatic conditions. We recently identified cytoskeletal scaffold protein, IQGAP3, as a highly specific isthmus stem cell factor during homeostasis (GUT, 2020). We further found that upon tissue damage, IQGAP3 was robustly induced in dormant stem cells, which acquired proliferating capacity to engage in tissue repair. The objective is detailed molecular characterization of these two types of stem cells.</li>\n</ul>\n</li>\n<li>IQGAP3 is also widely expressed in rapidly proliferating areas of gastric cancer. We call IQGAP3 the “common denominator of homeostasis, tissue repair and cancer”. Tumors have been described as “wounds that do not heal (Dvorak, 1986)”. We will investigate the possibility that elevated IQGAP3 expression during chronic tissue damage induces cell plasticity and redirects cell fate to drive malignant transformation.</li>\n<li>We have identified transcription factors responsible for the exclusive expression of IQGAP3 in stem cells. We have also found the proteins that interact with and stabilize the IQGAP3 mRNA in stem cells. We will study the role of IQGAP3 in the formation of stomach epithelial stem cells during development. Conversely, we found that depletion of these transcription factors in undifferentiated cancer cells induced differentiation as well as reduced cancer cell properties.  Understanding how these factors regulate IQGAP3 will lead to novel insights on induction of terminal differentiation as cancer therapy for aggressive tumor types.</li>\n<li>The fact that IQGAP3 is expressed not only in gastric but virtually all other types of cancer cells indicates a fundamental role for IQGAP3 in cancer growth. Developing drugs to inhibit IQGAP3 activity will be important.</li>\n</ol>\n\n\nQualifications\n\n\nWe seek a highly motivated and innovative postdoctoral fellow with the ability to work independently and as part of a team. Candidates should have PhD and/or MD degree with a strong background in molecular biology, biochemistry and cell biology. Prior experience with using mouse models to study cancer and 1-2 years of postdoctoral experience in these areas are required. \n\n\nApplications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work, and names and contact information (email and telephone numbers) of 2 referees. Please also include a summary of your research experience.\n\n\n","pdfUrl1":null,"location":"Singapore","location1":"아시아","location2":null,"location3":null,"type":"2","applyUrl":"https://careers.nus.edu.sg/NUS/job/Kent-Ridge-Research-Fellow%28-Cancer-Science-Institute%29-Kent/5814944/","fileUrl1":null,"fileUrl2":null,"fileUrl3":null,"fileUrl4":null,"fileUrl5":null,"fileUrl6":null,"fileUrl7":null,"workingHour":"Full Time","contractType":"Permanent","salary":null,"original_id":"UNI|278998","original_domain":"timeshighereducation.com","original_url":"https://www.timeshighereducation.com/unijobs/listing/278998","original_isPremium":null,"closeType":1,"closedAt":"2022-02-24T00:00:00.000Z","requireEducation":10,"managerTel":"","managerFax":null,"managerEmail":null,"managerName":"NATIONAL UNIVERSITY OF SINGAPORE","managerPhone":null,"managerAddress":"Singapore","log_hit":2,"log_like":0,"publishState":1,"organizationName":null,"organizationName_en":null,"organizationName_alt":null,"del_yn":"N","createdAt":"2022-01-25T18:22:54.000Z","updatedAt":"2022-01-25T18:22:54.000Z"},"organization":{"organizationId":483,"lv1Id":null,"lv2Id":null,"name":"National University of Singapore","name_en":"National University of Singapore","name_alt":",","introduction":"As Singapore’s flagship university and among Asia’s best, the <a href=\"http://www.nus.edu.sg/\">National University of Singapore (NUS)</a> offers a global approach to education, research and entrepreneurship, with a focus on Asian perspectives and expertise.&nbsp;Our 17 faculties across three campuses in Singapore – Kent Ridge, Bukit Timah and Outram – provide a rigorous broad-based curriculum underscored by cross-faculty enrichment. We have pioneered many innovative academic programmes which include student exchange, entrepreneurial internships at <a href=\"https://enterprise.nus.edu.sg/educate/nus-overseas-colleges\">12 NUS Overseas Colleges</a>, as well as double, joint and concurrent degree programmes with some of the world’s best universities. Close to 40,000 students from 100 countries enrich our vibrant and diverse campus community.&nbsp;The University’s multidisciplinary and real-world approach to education, research and entrepreneurship enables us to work closely with industry, governments and academia to address crucial and complex issues relevant to Asia and the world. Researchers in our faculties, 29 university-level research institutes, research centres of excellence and corporate labs focus on themes that include energy, environmental and urban sustainability; treatment and prevention of diseases common among Asians; active ageing; advanced materials; as well as risk management and resilience of financial systems. The University’s latest research focus is to use data science, operations research and cybersecurity to support Singapore's Smart Nation initiative. We also strive to create a supportive and innovative environment to promote creative enterprise within our community.","logoImg":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/다운로드(2)_1347216054377.png","logoImgSquare":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/bin/1200px-NUS_coat_of_arms_196665413153.svg","homepageUrl":"http://www.nus.edu.sg","infoUrl":"https://www.timeshighereducation.com/world-university-rankings/national-university-singapore","country":"SG","state":"Singapore","location":"아시아","address":"21 Lower Kent Ridge Road, 119077, Singapore","phoneNumber":"+65 6516 6666","faxNumber":"","type":1,"univType1":"대학","univType2":"대학교","univType3":"","univType4":"본교","establishedAt":"1970-01-01T00:00:00.000Z","count_majors":null,"count_students":null,"meta_competitiveness":"","publishState":1,"updatedAt":"2020-04-03T18:01:08.000Z","createdAt":"2020-03-04T20:13:07.000Z","default_1_bannerImage":null,"default_1_bannerImageMobile":null,"default_2_bannerImage":null,"default_2_bannerImageMobile":null,"default_3_bannerImage":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/production/images/1644197582127/special_NUS.jpg","default_3_bannerImageMobile":null}}