Research Associate in Protein Design in the Cell - JOBS.ac.kr(잡스) - 대한민국 최대 석박사 채용정보, 잡스!

{"job":{"jobId":640,"fk_accountId":null,"fk_organizationId":544,"fk_adminAccountId":null,"title":"Research Associate in Protein Design in the Cell","description":"\nResearch Associate in Protein Design in the Cell   \nJob number ACAD104411\nDivision/School School of Chemistry\nContract type Open Ended\nWorking pattern Full time\nSalary £33,797 - £38,017 per annum\nClosing date for applications 27-Feb-2020 \nA post-doctoral position is available to develop functional de novo protein designs that operate in living cells. \nThis BBSRC-funded post is available for 2 years.  The position is between the protein design laboratory of Prof Dek Woolfson (Chemistry and Biochemistry) and the bacterial cell biology laboratory of Prof Nigel Savery (Biochemistry).  See: Smith et al. (2019) ACS Synth Biol 8 1284. DOI: 10.1021/acssynbio.8b00501.\nSpecifically, the work will be to develop de novo protein-protein interactions (PPIs) that operate in E. coli and mammalian cells and orthogonally to the endogenous proteomes and interactomes.  The project will build on Woolfson’s set of de novo coiled-coil domains (Fletcher, et al. (2012), ACS Synth Biol 1, 240. DOI:10.1021/Sb300028q; Thomas, et al. (2013), J Am Chem Soc 135, 5161. DOI: 10.1021/Ja312310g; Rhys, et al. (2019) J Am Chem Soc 141 8787. DOI: 10.1021/jacs.8b13354) and Savery’s expertise in transcriptional control (Annunziata, et al. (2017), ACS Synth Biol 6, 1816. DOI: <a data-mz=\"\" href=\"https://doi.org/10.1021/acssynbio.7b00109\" rel=\"no-follow\">10.1021/acssynbio.7b00109</a>; Haines, et al. (2014) PNAS 111, 4037. DOI: <a data-mz=\"\" href=\"https://doi.org/10.1073/pnas.1322350111\" rel=\"no-follow\">10.1073/pnas.1322350111</a>).  The aim is to build de novo PPIs that can activate and repress targeted genes with tight control.  A further aim, which is in collaboration with AstraZeneca, is to make these de novo PPIs that respond to small-molecule drugs and, thus, to control transcription by switching the PPIs on and off with the small molecules.\nThe position would be best suited to a talented and ambitious early career researcher with an interest in applying de novo protein design in synthetic biology.  Essential skills for this role include: experience with the de novo design, synthesis and structural characterisation of synthetic peptides; the design, construction and expression of synthetic genes in E. coli; and biochemical and biophysical whole-cell assays such as FACS.  Experience in the design and screening of gene libraries would be an advantage, as would a knowledge mammalian cell biology; however, neither of these are essential for applicants at this stage.\nFor informal enquiries, please contact: d.n.woolfson@bristol.ac.uk\nWe welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.\n","pdfUrl1":null,"location":"Bristol (City Centre), City of Bristol (GB)","location1":"유럽","location2":null,"location3":null,"type":"2","applyUrl":"https://emea3.recruitmentplatform.com/appproc/index.cfm?event=createSessionAfterSessionClear&bSessionClear=true&ID=Q50FK026203F3VBQBV7V77V83&jobboard=0&nPTID=181499&nProfileIdFoundInAGP=&sType=THES&utm_source=THES&utm_medium=paid&utm_campaign=THES","fileUrl1":"","fileUrl2":"","fileUrl3":"","fileUrl4":"","fileUrl5":null,"fileUrl6":null,"fileUrl7":null,"workingHour":"Full Time","contractType":"Fixed Term","salary":"£33,797 - £38,017 per annum","original_id":"UNI|194605","original_domain":"https://www.timeshighereducation.com/unijobs","original_url":"https://www.timeshighereducation.com/unijobs/listing/194605/research-associate-in-protein-design-in-the-cell-/?LinkSource=PremiumListing","original_isPremium":"true","closeType":1,"closedAt":"2020-02-27T00:00:00.000Z","requireEducation":10,"managerTel":"","managerFax":"","managerEmail":"","managerName":"UNIVERSITY OF BRISTOL","managerPhone":"","managerAddress":null,"log_hit":5,"log_like":0,"publishState":1,"organizationName":null,"organizationName_en":null,"organizationName_alt":null,"createdAt":"2020-01-28T09:00:00.000Z","updatedAt":null},"organization":{"organizationId":544,"lv1Id":null,"lv2Id":null,"name":"University of Bristol","name_en":"University of Bristol","name_alt":",","introduction":"Founded in 1876, the University of Bristol combines academic excellence with innovation. Students can choose from more than 500 courses at all levels, from foundation degrees to PhDs.&nbsp;Ranked joint fifth in the UK for research,* the University is home to more than 25,000 students from across 150 countries. The main campus is at the heart of the historic but vibrant city of Bristol, just a two-hour journey from London. With its diverse culture, independent spirit and acres of green space, the city was named the UK’s best place to live by the&nbsp;Sunday Times in 2017.&nbsp;Bristol graduates are influential in academia, policy and practice across the world. The University’s alumni network includes leading figures in science, industry, politics and the arts.&nbsp;","logoImg":"","logoImgSquare":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/bristol_725531969443.jpg","homepageUrl":"http://www.bristol.ac.uk","infoUrl":"https://www.timeshighereducation.com/world-university-rankings/university-bristol","country":"GB","state":"Bristol","location":"유럽","address":"Senate House, Tyndall Avenue, Bristol, Avon, BS8 1TH, United Kingdom","phoneNumber":"+44 117 928 9000","faxNumber":"","type":1,"univType1":"대학","univType2":"대학교","univType3":"","univType4":"본교","establishedAt":"1875-12-31T00:00:00.000Z","count_majors":null,"count_students":null,"meta_competitiveness":"","publishState":1,"updatedAt":"2020-04-16T14:13:49.000Z","createdAt":"2020-03-04T20:13:07.000Z","default_1_bannerImage":null,"default_1_bannerImageMobile":null,"default_2_bannerImage":null,"default_2_bannerImageMobile":null,"default_3_bannerImage":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/BRISTOL2_1188802760434.jpg","default_3_bannerImageMobile":"https://s3.ap-northeast-2.amazonaws.com/jobs.ac.kr/dev/images/BRISTOL2_759017476913.jpg"}}